The group reports a great way to add in CO2 into the flow of a Grignard coming down the pipe to form carboxylates in high yield. A schematic of one of the examples if shown below. As you can see, the aryl-Grignard is sent flowing at a specific concentration as THF is also sent on its’ way, while a pressurized line of CO2 intercepts (in-line quenching is always cool — maybe I was always doing flow- cannula based quenching, LOL!) and keeps the flow going out the other end.
A look at the set-up — looks a little different than a coil-loop diagram. Happy Reading!