Gas additions in flow tube-in-tube design

Re-posting from Allfordrugs on the formation of carboxylic acids in flow chemistry with the use of CO2 in-line from a report in Angewandte Chemie 2011 at the University of Cambridge.

The group reports a great way to add in CO2 into the flow of a Grignard coming down the pipe to form carboxylates in high yield. A schematic of one of the examples if shown below. As you can see, the aryl-Grignard is sent flowing at a specific concentration as THF is also sent on its’ way, while a pressurized line of CO2 intercepts (in-line quenching is always cool — maybe I was always doing flow- cannula based quenching, LOL!) and keeps the flow going out the other end.

Screen Shot 2014-10-25 at 10.00.33 AM

 

A look at the set-up — looks a little different than a coil-loop diagram. Happy Reading!

Screen Shot 2014-10-25 at 10.00.20 AM
Pretty big tubing: Swagelock and PTFE tubing (described in article)
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