Odourless isocyanide continuous flow reactions: Multistep, multicomponent

I suppose I was bound to run across John Knight’s report on flow chemistry (Scientific Update)– as he mentioned his gravitation to multicomponent reactions I couldn’t wipe the grin off my face. At any rate — I have linked his post, and talk a little about the flow reaction described.

John mentions a report from P. Kim et al in Angewandte Chemie 2013 on the use of continuous flow chemistry applied to generation of an isocyande in a flow reactor, into a separator and continued into a new flow reactor that is being fed additional reactants to perform a multistep, and Ugi or Passerini multicomponent reaction. A must add to your collection of flow reaction chemistry opportunities. Happy Reading!

Screen Shot 2014-10-25 at 10.35.28 AM


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