I have recently had the opportunity to meet and work with Dr. Frank Gupton. He has made a career in the chemical development of drug candidates at more than one pharma entity (Hoechst and BI to name a couple)….and has taken his talents back to academia at VCU as the department chair of the Chemical and Life Science Engineering department…..quite a facility. Although industry has made an impression in his career, he is making a tremendous impact in continuous methodologies in manufacturing and drug discovery strategies using flow chemistry — and in several areas: catalyst development, API production, impactful methodology including hydrogenation, C-C coupling catalyst development, C-H activation and general approaches to specific targets. This practical paradigm is leading the way with industrial chemists building back into technology shifts across the pharma industry. One recent endeavor I have had the opportunity to join — Center for Rational Catalyst Design – a consortium with the University of South Carolina (with John Regalbuto) and some of the leading catalyst researchers in the country — all with a focus on development and research directed to new catalysts and basic research designed to impact all chemical industries. Anyone in pharma or metal catalyst design should take the time to contact Frank and the CeRCAS for an opportunity to stay in front of the newest developments in ongoing chemical catalyst design and flow chemical methods.
A recent example can be found in a continuous flow application in the synthesis of telmisartan. That said you should stay tuned some some of the newer work in catalyst and method development work……I will keep you posted.