Divergent flow synthesis by stream splitting (Changing the Game)

So there are several aspects to cover from a recent review article from Green Processing and Synthesis (Green Process Synth 2013: Flow chemistry approaches directed at improving chemical synthesis), but one thing that caught my attention (there were several) had to do with the formation of a substrate which was then split into several streams and reacted with additional components to produce products in separate lines. Man talk about a way to produce analogs or even several advanced intermediates to be used again.

Following a prior sequence to form specific ynone products, the Durham group added additional cools and streams to have this substrate react with several other reactants at different temperatures and flow rates independently to form products in separate in-line receiving flasks. Take a look at the set-up and the scheme below to see the innovative approach in using this technology — this would be the model in my lab wet chem set-up moving forward for a number of transformations. Love it. Happy Reading!

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